Wakefield Lab at the Jobst Vascular Research Laboratory

1. HL070766, Wakefield (PI), 12/01/2006-11/30/2011, NIH/NHLBI



Procoagulant Microparticles: Novel Determinants of Venous Thrombogenesis

This project focuses on the role of microparticles in venous thrombogenesis using both animal models and also clinical samples. We are attempting to also use biomarkers developed in animal models to aid in the clinical diagnosis of DVT.

2. HL089407, PPG, (Lawrence, PI), 04/01/2008-03/31/2013, NIH
   Novel Targets in Thrombosis and Atherosclerosis



Project 2: Role of PAI-1 in Venous Thrombosis (Wakefield, PI)

This project evaluates the role of PAI-1 in various animal models of venous thrombosis, and determines synergism of PAI-1 with coagulation and cholesterol abnormalities. I am responsible for one of the projects of this PPG.

3. HL095091 (Wakefield and Wagner, Co-PIs), 09/01/2008-08/31/2013, NIH RFA HL-08-002



Novel Therapeutic Targets for Venous Thromboembolism

This project will determine the role of VWF and P-selectin in venous thrombosis in various animal models and in primates. We will also develop new agents to target these molecules for the prevention and treatment of venous thrombosis, and expand on biomarkers evaluated in animal models to aid in the clinical diagnosis of DVT.

4. HL076123 (Wakefield, PI), 09/01/09-08/31/14, NIH Training and Special Program



Vascular Surgery: Research Training in Vascular Biology

This project is a training grant for Vascular Biology, encompassing faculty from multiple disciples. The common theme is an emphasis on the basic study of vessel wall biology and vascular pathology with the ultimate goal to produce the next generation of leaders in academic vascular sciences.