Thomas W. Wakefield, M.D.
James C. Stanley Professor of Vascular Surgery
5463 Cardiovascular Center
1500 E. Medical Center Drive
Ann Arbor, MI 48109-5867
Appointments, Nursing, Information: (888) 287-1082 (toll free)
After Hours Paging: (734) 936-6267
Medical Records: (734) 232-4480 (fax)
Academic Office: (734) 936-5820
Fax: (734) 647-9867
Procoagulant Microparticles: Novel Determinants of Venous Thrombogenesis
This project focuses on the role of microparticles in venous thrombogenesis using both animal models and also clinical samples. We are attempting to also use biomarkers developed in animal models to aid in the clinical diagnosis of DVT.
Project 2: Role of PAI-1 in Venous Thrombosis (Wakefield, PI)
This project evaluates the role of PAI-1 in various animal models of venous thrombosis, and determines synergism of PAI-1 with coagulation and cholesterol abnormalities. I am responsible for one of the projects of this PPG.
Novel Therapeutic Targets for Venous Thromboembolism
This project will determine the role of VWF and P-selectin in venous thrombosis in various animal models and in primates. We will also develop new agents to target these molecules for the prevention and treatment of venous thrombosis, and expand on biomarkers evaluated in animal models to aid in the clinical diagnosis of DVT.
Vascular Surgery: Research Training in Vascular Biology
This project is a training grant for Vascular Biology, encompassing faculty from multiple disciples. The common theme is an emphasis on the basic study of vessel wall biology and vascular pathology with the ultimate goal to produce the next generation of leaders in academic vascular sciences.