Wakefield Lab at the Jobst Vascular Research Laboratory

1. P-selectin is Central to Venous Thrombosis Pathogenesis
   Investigators: Thomas W. Wakefield, MD (PI), Daniel Myers, Jr, DVM, MPH, Peter Henke, MD
   The project evaluates the role of P-selectin, platelet-derived microparticles, and leukocyte-derived microparticles in the pathogenesis of venous thrombosis.
2. Prospective Investigation of Pulmonary Embolism Diagnosis II
   Investigators: Paul Stein MD (PI), Jack Weg MD (PI, Pulmonary Medicine, Subcontract), Thomas W. Wakefield, MD (Ultrasound Chair)
   The project compares spiral CT scanning to pulmonary angiography with the use of lower extremity venous duplex imaging for the diagnosis of pulmonary embolism.
3. Aging Venous Thrombi with Ultrasound Elasticity Imaging
   Investigators: Jon Rubin MD (PI, Radiology), Stanislav Emelianov PhD (Biomechanical Engineering), Matthew O'Donnell PhD (Biomedical Engineering), Daniel Myers, Jr DVM, MPH, Thomas W. Wakefield, MD
   This project will use a new technique of elasticity quantification to age venous thrombi.
4. Thrombus Resolution is CXC Chemokine Dependent
   Investigators: Peter Henke MD (PI), Thomas W. Wakefield, MD
   The project evaluates factors responsible for thrombus resolution after DVT.
5. Inhibition of DVT Induced Inflammation and Thrombosis by rPSGL-Ig
   Investigators: Thomas Wakefield, MD (PI), Daniel Myers, Jr, DVM, MPH, Shirley Wrobleski, BS, LVT, Frank Londy, RT (Radiology), Peter Henke, MD, Lazar J. Greenfield, MD
   This project evaluates the use of a PSGL-1 receptor antagonist to limit inflammation and thrombosis during and after venous thrombosis produced by temporary venous balloon occlusion. It also assesses the ability of the same PSGL-1 receptor antagonist to augment spontaneous venous thrombolysis.
6. Inhibition of Deep Vein Thrombosis (DVT)- Induced Inflammation and Thrombosis by Melagatron
   Investigators: Thomas W. Wakefield, MD (PI), Daniel Myers, Jr, DVM, MPH, Shirley Wrobleski, BS, LVT
   This project will assess the effects of Melagatron in an IVC ligation model.
7. Supervised Calf Muscle Exercise in Patients with Chronic Venous Insufficiency and Wearing Compression Stockings
   Investigators: Paul Zajkowski, BS, Thomas Wakefield MD, Mary Proctor MS, Thomas Draper (Preventive Cardiology)
   This project will determine the effect of a supervised exercise program on venous insufficiency.
8. Enhancing Intrinsic Regeneration to Tissue Engineer a Peripheral Nerve Graft
   Investigators: William Kuzon (PI, Plastic Surgery), Thomas Wakefield MD
   Funding: UM Center for Biomedical Engineering Research
   The project will examine the role of inflammation and its inhibition in peripheral nerve graft biology.