Henke Lab at the Jobst Vascular Research Laboratory

ONGOING RESEARCH

Deep Venous Thrombosis Resolution is CXC Chemokine-dependent

Investigators: Peter K. Henke, MD, Andrea Varga, BS, Pasu Sukheepod, MD, Thomas W. Wakefield, MD
The purpose of this study is to define the role of CXC chemokines and neutrophils in DVT resolution, along with their effect on PMN lytic activity in vitro.

P-selectin and DVT mediated pathogenesis, Co-investigator

This project will evaluate the role of P-selectin in the pathogenesis of venous thrombosis.

Role of endothelial damage in vein wall fibrotic response after DVT

This study will evaluate the mechanisms of vein wall re-endothelialization after DVT and therapies to accelerate this response. Rodent models and in vitro analyses will be done.

Matrix metalloproteinases and vein wall damage after DVT

The goal of this project is to evaluate the role of the MMP-2 and -9 in vein wall remodeling after DVT in an animal model (with varying thrombotiic conditions), as well as in a human cohort in whom acute DVT has occurred.

uPA and MMP activation in DVT resolution

This project will evaluate the reciprocal interaction of the MMPs and uPA in the vein wall response and how it affects thrombus resolution in rodent models. Modulation of the MMP response will also be done with lymphokines such as interferon-gamma.