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David G. Beer, Ph.D.
David George Beer, Ph.D.
Professor of Surgery, Section of Thoracic Surgery
Professor of Radiation Oncology

Recent Publications

  1. Weir BA, Getz G, Woo MS, Perner S, Beroukhim R, Ding L, Lin WM, Province MA, Kraja A, Johnson L, Shah K, Thomas RK, Barletts JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar A, Giordano T, Greulich H, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna J, Morgan MB, Nadel M, Orringer MB, Osbourne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Sato M, Shepard F, Spitz MR, Tsao M-S, Twoney D, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis W, Pao W, Rubin MA, Gabriel S, Gibbs R, Varmus H, Wilson RK, Lander E, Meyerson M. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007 Nov 4(Epub ahead of print). PMID: 18641660.
  2. Wang S, Nan B, Zhu J, Beer DG. Doubly penalized Buckley-James method for survival data with high-dimensional covariates. Biometrics 2007 Aug 3; [Epub ahead of print]. PMID: 17680828.
  3. Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun B, David S, Beer DG, Agarwal R, Abraham JM, Metlzer SJ. Hypermethylation of the AKAP12 Promoter is a Biomarker of Barrett's-Associated Esophageal Neoplastic Progression. Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):111-7. PMID: 18199717.
  4. DiFeo A, Feld L, Beer DG, Martignetti JA, Narla G. A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response. Cancer Res. 2008 Feb 4; [Epub ahead of print] PMID: 18250346.
  5. Perner S, Wagner PL, Demichelis F, Mehra R, Lafargue CJ, Moss BJ, Arbogast S, Soltermann A, Weder W, Giordano TJ, Beer DG, Rickman DS, Chinnaiyan AM, Moch H, Rubin MA. EML4-ALK fusion lung cancer: a rare acquired event. Neoplasia. 2008 Mar;10(3):298-302. PMID: 18320074.
  6. Shedden K, Taylor JMG, Enkemann SA, Tsao MS, Yeatman TJ, Eschrich S, Jurisica I, Gerald WL, Venkatraman ES, Meyerson M, Kuick R, Dobbin KK, Lively T, Giordano TJ, Misek DE, Chang AC, Zhu CQ, Strumpf D, Hanash S, Shepherd FA, Ding K, Seymour L, Naoki K, Pennell N, Weir B, Verhaak R, Ladd-Acosta C, Golub T, Gruidl M, Szoke J, Zakowski M, Rusch V, Kris M, Viale A, Motoi N, Travis W, Sharma A. Jacobson JW, Beer DG. Gene Expression-Based Survival Prediction in Lung Adenocarcinoma: A Multi-Site, Blinded Validation Study Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma. Nature Medicine July 20, 2008(Epub ahead of print). PMID: 18641660.
  7. Watanabe N, Takaoka M, Sakurama K, Tomono Y, Hatakeyama S, Ohmori O, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Beer DG, Nagatsuka H, Tanaka N, Naomoto Y.Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo. Clin Cancer Res. 2008 Jul15;14(14):4631-9. PMID: 18628478.
  8. Shammas MA, Qazi A, Batchu RB, Bertheau RC, Wong JY, Rao MY, Prasad M, Chanda D, Ponnazhagan S, Anderson KC, Steffes CP, Munshi NC, De Vivo I, Beer DG, Gryaznov S, Weaver DW, Goyal RK.Telomere maintenance in laser capture microdissection-purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo. Clin Cancer Res. 2008 Aug 1;14(15):4971-80. PMID: 18676772.
  9. Jin Z, Cheng Y, Olaru A, Kan T, Yang J, Paun B, Ito T, Hamilton JP, David S, Agarwal R, Selaru FM, Sato F, Abraham JM, Beer DG, Mori Y, Shimada Y, Meltzer SJ. Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. Int J Cancer. 2008 Nov 15;123(10):2331-6. PMID: 18729198.
  10. Albertus DL, Seder CW, Chen G Wang X, Hartojo W, Lin L, Silvers A, Thomas DG, Giordano TJ, Chang AC, Orringer MB, Bigbee WL, Chinnaiyan AM, Beer DG. AZGP1 expression is epigenetically regulated and its autoantibody predicts survival in lung adenocarcinoma. J. Thoracic Oncology 2008 Nov;3(11):1236-1244. PMID: 18978557.
  11. Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence M, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good P, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008 Oct 23;455(7216):1069-75. PMID: 18948947.
  12. Guo NL, Wan YW, Tosun K, Lin H, Msiska Z, Flynn DC, Remick SC, Vallyathan V, Dowlati A, Shi X, Castranova V, Beer DG, Qian Y. Confirmation of gene expression-based prediction of survival in non-small cell lung cancer. Clin Cancer Res. 2008 Dec 15;14(24):8213-20. PMID: 19088038.
  13. Seder CW, Hartojo W, Lin L, Silvers A, Wang Z, Thomas DG, Giordano TJ, Chen G,Chang AC, Orringer MB, Beer DG. INHBA Overexpression Promotes Cell Proliferation and May Be Epigenetically Regulated in Esophageal Adenocarcinoma. J. Thoracic Oncology. Thorac Oncol. 2009 Feb 23. [Epub ahead of print] PMID: 19240652.
  14. Seder CW, Hartojo W, Lin L, Silvers A, Wang Z, Thomas DG, Giordano TJ, Chen G,Chang AC, Orringer MB, Beer DG. Upregulated INHBA Expression May Promote Cell Proliferation and Is Associated with Poor Survival in Lung Adenocarcinoma. Neoplasia. 2009 Apr;11(4):388-96. PMID: 19308293.
  15. Raponi M, Dossey L, Jatkoe T, Wu X, Chen G, Fan H, Beer DG. MicroRNA Classifiers for Predicting Prognosis of Squamous Cell Lung Cancer. Cancer Research. 2009; 69: (14). July 15, 2009 5776-5783.
  16. Kausar T, Ahsan A, Hasan Md.R, Lin L,Beer DG, Ralhan R. Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines. Int J Cancer. 2009 Aug 14. [Epub ahead of print] PMID: 19685492.
  17. Ramos AH, Dut A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Steidl A-C, Tanaka K, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna J, Chirieac L, Lindeman N, Giordano TG, Beer DG, Wagner P, Wistuba I I, Rubin MA, Meyerson M. Amplification of Chromosomal Segment 4q12 in Non-small Cell Lung Cancer. Cancer Biology & Therapy (in press).
  18. Hassan KA, Chen G, Kalemkerian GP, Wicha M, Beer DG. An embryonic stem cell-like signature identifies poorly-differentiated lung adenocarcinoma but not squamous carcinoma. Clin Cancer Research 2009 Oct 15;15(20):6386-90. Oct 6. PubMed PMID: 19808871.
  19. Bass A, Watanabe H, Yul S, Mermel C, Perner S, Verhaak R, Kim SY, Wardell L, Tamayo P Gat-Viks I, Ramos A, Woo MS, Weir B, Gets G, Beroukhim R, O'Kelly M, Dutt A, Rozenbaltt-Rozen O, Dziunycz P, Komisarof J, Chirieac L, LaFargue V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Brose M, Ribeiro U, Marie SK, Shivdasanil RA, Tsao MS, Rubin M, Wong K, Regev A, Hahn WC, Beer DG, Rustgi A, Meyerson M. SOX2 is an Amplified Oncogene in Squamous Cell Esophageal and Lung Carcinomas. Nature Genetics Nov;41(11):1238-42. Epub 2009 Oct 4. PubMed PMID: 19801978.
  20. Beroukhim R, Mermel CH, D Porter, G Wei, S Raychaudhuri, J Donovan, J Barretina1, JS Boehm, J Dobson, M Urashima, K McHenry, R Pinchback, AH Ligon, J Cho, L Haery, H Greulich, M Reich, W Winckler, BA Weir, K Tanaka, DY Chiang, AJ Bass, A Loo, C Hoffman, J Prensner, T Liefeld, D Yecies,nS Signoretti, E Maher, FJ Kaye, H Sasaki, JE Tepper, JA Fletcher, J Baselga, M Tsao, MA Rubin, PA Janne, MJ Daly, C Nucera, RL Levine, BL Ebert, S Gabriel, AK Rustgi, CR Antonescu, M Ladanyi, A Leta, LA Garraway, M Loda, DG Beer, LD True, A Okamoto, SL Pomeroy, S Singer, ES Lander, G Getz, TR Golub, WR Sellers, M Meyerson. The landscape of copy number alterations across multiple human cancers. Nature. 2010 Feb 18;463(7283):899-905.PMID: 20164920
  21. Boonstra JJ, van Marion R, Beer DG , Lin L, Chaves P, Ribeiro C, Pereira AD, Roque L, Darnton SJ, Altorki NK, Schrump DS, Klimstra DS, Tang LH, Eshleman JR, Alvarez H , ShimadaY, van Dekken H, Tilanus HW, Dinjens WNM. Contaminated Cell Lines Threaten the Development of Treatment Strategies for Esophageal Adenocarcinoma. J. Natl. Cancer Inst. 2010 Feb 24;102(4):271-4. Epub 2010 Jan 14.PMID: 20075370
  22. AL Silvers, L Lin, AJ Bass, Z Wang, G Chen, DG Thomas, J Lin, M Meyerson, DG Beer, AC. Chang. Decreased selenium binding protein 1 (SELENBP1) in esophageal adneocarcinoma results from post-transcriptional and epigenetic mechanisms and affects chemosensitivity. Clin Cancer Res. 2010 Apr 1;16(7):2009-21. Epub 2010 Mar 23.PMID: 20332323
  23. Hartojo W, Silvers AL, Thomas DG, Seder CW, Lin L, Rao H, Wang Z, Greenson JK, Giordano TJ, Orringer MB, Rehemtulla A, Bhojani MS, Beer DG, Chang AC. Curcuminpromotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma. Transl Oncol. 2010 Apr;3(2):99-108. PubMed PMID: 20360934; PubMed Central PMCID: PMC2847317.
  24. Li M, Anastassiades CP, Joshi B, Komarck CM, Piraka C, Elmunzer BJ, Turgeon DK, Johnson TD, Appelman H, Beer DG, Wang TD. Affinity Peptide for Targeted Detection of Dysplasia in Barrett's Esophagus. Gastroenterology. 2010 Nov;139(5):1472-80. PMID: 20637198.
  25. Bryant CM, Albertus DL, Kim S, Chen G, Brambilla C, Guedj M, Arima C, Travis WD, Yatabe Y, Takahashi T, Brambilla E, Beer DG. Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways: an international validation study. PLoS One. 2010 Jul 22;5(7):e11712. PubMed PMID:20661423; PubMed Central PMCID: PMC2908611.
  26. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011 Feb;6(2):244-85. PubMed PMID: 21252716.