Thoracic Surgery
Lin Lin, M.D., Ph.D.
Research Investigator, Section of Thoracic Surgery

Fax: (734) 763-0323

Publications

  1. Lin L, Wang Z, Prescott MS, van Dekken H, Thomas DG, Giordano TJ, Chang AC, Orringer MB, Gruber SB, Moran JV, Glover TW, Beer DG. (2006) Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma. Genes Chromosomes Cancer. 45:319-31.
  2. Miller CT, Lin L, Casper AM, Lim J, Thomas DG, Orringer MB, Chang AC, Chambers AF, Giordano TJ, Glover TW, Beer DG. (2006) Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma. Oncogene, 25:409-18 (first co-author).
  3. Chen G, Bhojani MS, Heaford AC, Chang DC, Laxman B, Thomas DG, Griffin LB, Yu J, Coppola JM, Giordano TJ, Lin L, Adams D, Orringer MB, Ross BD, Beer DG, Rehemtulla A. (2005) Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proc. Natl. Acad. Sci. U.S.A., 102:12507-12.
  4. Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JMG, Orringer MB, and Beer DG. (2004) Melanoma-associated Antigens in Esophageal Adenocarcinoma: Identification of Novel MAGE-A10 Splice Variants. Clin. Cancer Res., 10:5708-16.
  5. Miller CT, Moy JR, Lin L, Schipper M, Normolle D, Brenner DE, Iannettoni MD, Orringer MB, and Beer DG. (2003) Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. Clin. Cancer Res., 9:4819-25.
  6. Miller CT, Aggarwal S, Lin TK, Dagenais SL, Contreras JI, Orringer MB, Glover TW, Beer DG, and Lin L. (2003) Amplification and Overexpression of the Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2 (DYRK2) Gene in Esophageal and Lung Adenocarcinomas. Cancer Res., 63:4136-43.
  7. Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR. (2003) Amplification and Overexpression of the L-MYC Proto-Oncogene in Ovarian Carcinomas. Am. J. Pathol., 162:1603-10.
  8. Lin L, Miller CT, Contreras JI, Prescott MS, Dagenais SL, Wu R, Yee J, Orringer MB, Misek DE, Hanash SM, Glover TW, and Beer DG. (2002) The Hepatocyte Nuclear Factor 3 Alpha Gene, HNF3? (FOXA1), on Chromosome Band 14q13 is Amplified and Overexpressed in Esophageal and Lung Adenocarcinomas. Cancer Res., 62:5273-9.
  9. Beer DG, Kardia SLR, Huang CC, Giordano, TJ, Misek DE, Lin L, Chen, G, Gharib TG, Thomas DG, Lizyness ML, Kuick R, Taylor JMG, Iannettonni MD, Orringer MB, and Hanash S. (2002) Gene Expression profiles define a high-risk group among stage I lung adenocarcinomas. Nature Med., 8:816-24.
  10. Lin L, Wang Y, Bergman G, Kelloff GJ, Lubet RA, and You M. (2001) Detection of differentially expressed genes in mouse lung adenocarcinomas. Exp. Lung Res., 27:217-29.
  11. Lin L, Prescott MS, Zhu Z, Singh P, Chun SY, Kuick RD, Hanash SM, Orringer MB, Glover TW, and Beer DG (2000) Identification and characterization of a 19q12 amplicon in esophageal adenocarcinomas reveals cyclin E as the best candidate gene for this amplicon. Cancer Res., 60:7021-7.
  12. Zhang Z, Lin L (co-first author), Liu G, Wang M, Hill J, Wang Y, You M, and Devereux TR (2000) Fine mapping and characterization of candidate lung tumor resistance genes for the Par2 locus on mouse chromosome 18. Exp. Lung Res., 26:627-39.
  13. Aggarwal S, Taneja N, Lin L, Iannettoni MD, Orringer MB, Rehemtulla A, and Beer DG (2000) Indomethacin-induced apoptosis in esophageal adenocarcinoma cells involves upregulation of BAX and translocation of mitochondrial cytochrome C independent of COX-2 expression. Neoplasia, 2:346-356.
  14. Lin L, Aggarwal S, Glover TW, Orringer MB, Hanash S, and Beer DG (2000) A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene. Cancer Res., 60:1341-7.
  15. Festing MF, Lin L, Devereux TR, Gao F, Yang A, Anna CH, White CM, Malkinson AM, and You M (1998) At Least Four Loci and Gender Are Associated with Susceptibility to the Chemical Induction of Lung Adenomas in A/J x BALB/c Mice. Genomics, 53:129-136.
  16. Lin L, Festing MF, Devereux TR, Crist K, Christiansen S, Wang Y, Yang A, Svenson K, Paigen B, Malkinson AM, and You M (1998) Additional evidence that the K-ras proto-oncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas1) gene. Exp. Lung Res., 24:481-497.
  17. Hu L, Lin L, Kellof GJ, Steele VE, Lubet RA, You M, and Wang Y (1997) Detection of differentially expressed genes in methylnitrosourea-induced rat mammary adenocarcinomas. J. Cellular Biochemistry (suppl), 28/29:117-124.
  18. Naggert JK, Svenson KL, Lin L, Cheah Y-C, Nishina PM, Mu J-L, Devereux TR, You M, and Paigen B (1997) An additional 136 SSLP markers typed for the AXB and BXA recombinant inbred mouse strains. Mamm. Genome, 8:209-211.
  19. Lin L, Pu W, Li TL, Ren HM (1993) Comparative research in medical teaching models abroad. In: China?s Medical Education System.
  20. Zhao SZ, Lin L. (1990) On the structure of higher medical education and the functions of three-year medical education system in China. J. Medical Education (Beijing), 3:9-12.
  21. Lin L (1988) A teaching program using complex credit system. J. Northwest Medical Education (Xi?an), 5:157-168.
  22. Lin L (1987) The medical curriculum design. J. Northwest Medical Education (Xi?an), 4:28-33.