Thoracic Surgery
Mark B. Orringer, M.D.
Professor and Head, Section of Thoracic Surgery
John Alexander Distinguished Professor

Recent Publications

  1. Chen G, Wang H, Miller CT, Thomas DG, Gharib TG, Misek DE, Giordano TJ, Orringer MB, Hanash SM, Beer DG. Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas. J of Pathology 2004;202:321-329.
  2. Patel HJ, Tan BB, Yee J, Orringer MB, Iannettoni MD. A 25-year experience with open primary transthoracic repair of paraesophageal hiatal hernia. J Thorac Cardiovasc Surg, 2004;127(3):843-849.
  3. Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JMG, Orringer MB, Beer DG. Melanoma-associated antigens in esophageal adenocarcinoma: Identification of Novel MAGE-A10 splice variants. Clin Can Res 2004;10:5708-5716.
  4. Gharib TG, Chen G, Huang CC, Misek DE, Iannettoni MD, Hanash SM, Orringer MB, Beer DG. Genomic and proteomic analyses of vascular endothelial growth factor and insulin-like growth factor-binding protein 3 in lung adenocarcinomas. Clin Lung Cancer 2004;5(5):307-12.
  5. Lin J, Raoof DA, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Bourner MJ, Bauer CT, Orringer MB, Beer DG. L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett?s adenocarcinoma. Neoplasia 2004;6(1):74-84.
  6. Gold JP, Begg WB, Fullerton D, Mathisen D, Olinger G, Orringer M, Verrier E. Successful implementation of a novel internet hybrid surgery curriculum: The early phase outcome of thoracic surgery prerequisite curriculum e-learning project. Annals of Surgery 2004;240(3):499-507.
  7. Dimick JB, Wainess RM, Upchurch GR, Iannettoni MD, Orringer MB. National Trends in Outcomes for Esophageal Resection. Annals Thorac Surg 2005;79:212-8.
  8. Itano H, Lee S, Kulick DM, Iannettoni MD, Williams DM, Orringer MB. Non-traumatic chest wall systemic to pulmonary artery fistula. Annals Thorac Surg, 2005;79(5):e29-31.
  9. Orringer MB. Transhiatal esophagectomy without thoracotomy. OpTechs TCVS, Spring 2005;10(1):63-83.
  10. Dimick JB, Goodney PP, Orringer MB, Birkmeyer JD. Specialty training and mortality after esophageal cancer resection. Ann Thorac Surg, 2005;80(1):282-6.
  11. Chen G, Bhojani MS, Heaford AC, Chang DC, Laxman B, Thomas DG, Griffin LB, Yu J, Coppola JM, Giordano TJ, Lin L, Adams D, Orringer MB, Ross BD, Beer DG, Rehemtulla A. Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. PNAS, 2005;102(35):12507-512.
  12. Gold JP, Begg WB, Fullerton D, Mathisen D, Orringer M, Verrier E. Evaluation of web-based learning tools: Lessons learned from the Thoracic Surgery Directors Association (TSDA) curriculum project three year experience. Annals Thorac Surg, 2005;80(3):802-9.
  13. Lin L,Wang Z, Prescott MS, van Dekken H, Thomas DG, Giordano TJ, Chang AC, Orringer MB, Gruber SB, Moran JV, Glover TW, Beer DG. Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma. Genes, Chromosomes and Cancer, 2006;45:319-331.
  14. Miller CT, Lin L, Casper AM, Lim J, Thomas DG, Orringer MB, Chang A, Giordano TJ, Glover TW, Beer DG. Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinomas. Oncogene, 2006;25(3):409-18.
  15. Beer DG, Moy JR, Hughes SJ, Lin L, Normolle D, Iannettoni MD, Orringer MB. Gene amplification in Barrett?s adenocarcinoma and Barrett?s adenocarcinoma cell lines. Submitted.
  16. McClelland M, White ES, Gray A, Carskadon SL, Zhao L, Orringer MB, Chang AC, Arenberg DA. Tumor-derived fibroblasts from non-small cell lung cancer are pro-angiogenic and promote tumor growth. Cancer Research, submitted 7/2005.
  17. Chen G, Wang X,Yu J, Varambally S, Yu J, Thomas DG, Wang Z, Fielhauer J,Ghosh D, Giordano TJ, Chang AC, Orringer MB, *Beer DG, *Chinnaiyan AM, (*Shared senior authorship). "Autoantibody Profiles for the Diagnosis and Prognosis of Lung Adenocarcinoma. Nature Medicine. Submitted.
  18. Lin J, Raoof DA, Thomas DG, Greenson JK, Giordano TJ, Orringer MB, Chang AC, Beer DG. Expression and Effect of Inhibition of the Ubiquitin-Conjugating Enzyme E2C in Esophageal Adenocarcinoma. Neoplasia. Submitted 10/2005.
  19. Ammori, JB, Pickens A, Chang AC, Orringer MB. Tension Chylothorax: Case Reports and a Review. Annals Thorac Surg. Submitted 10/2005.
  20. McClelland, MR, Carskadon S, Zhao L, White ES, Orringer MB, Pickens A, Chang A, Arenberg DA. Diversity of the angiogenic phenotype in non-small cell lung cancer. AACR. Submitted 06/2006.

Recent Chapters In Books

  1. Orringer MB. Esophageal tumors. In Cameron, JL (ed.) Current Surgical Therapy, 6th edition. Mosby Co., St. Louis, 1998, 58-62.
  2. Orringer MB. Resection of the esophagus. Chapter 125. In Shields TW (ed). General Thoracic Surgery, 5th Edition, Lippincott, Williams & Wilkins, Philadelphia, 1999, pp. 1697-1722.
  3. Shapiro B, Orringer MB, Gross MD. Mediastinal paragangliomas and pheochromocytomas. Chapter 184. In Shields TW (ed). General Thoracic Surgery, 5th Edition, Lippincott, Williams, & Wilkins, Philadelphia, 2000, pp. 2333-2355.
  4. Orringer MB. Current Status of Transhiatal Esophagectomy. Chapter 8 in Cameron J (ed) Advances in Surgery - Volume 34 ? Mosby, Inc., St. Louis, MO, 2000, pp. 193-236.
  5. Zwischenberger JB, Alpard SK, Orringer MB. Esophagus. Chapter 37 In Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL (eds). Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 16th Edition. WB Saunders, Philadelphia, 2000, pp. 709-51.
  6. Orringer MB. Tumors, Injuries, and Miscellaneous Conditions of the Esophagus. Chapter 20 in Greenfield LJ, Oldham KT, Zelenock GB, Lillemoe KD, Mulholland M (eds.). Surgery ? Scientific Principles and Practice ? Third Edition, Lippincott, Williams & Wilkins, Philadelphia, 2001, pp. 692-735.
  7. Orringer MB. Transhiatal esophagectomy without thoracotomy. In Pearson FG, Cooper JD, Deslauriers J, Ginsberg RJ, Hiebert CA, Patterson GA, Urschel HC, Jr. (eds). Esophageal Surgery ? 2nd Edition. Churchill Livingstone, New York, 2002, pp. 834-853.
  8. Orringer MB. Resection of carcinoma involving the cervicothoracic esophagus ? cervical exenteration. In Pearson FG, Cooper JD, Deslauriers J, Ginsberg RJ, Hiebert CA, Patterson GA, Urschel HC, Jr. (eds). Esophageal Surgery ? 2nd Edition. Churchill Livingstone, New York, 2002, pp. 880-887.
  9. Orringer MB. Transhiatal esophagectomy without thoracotomy. Chapter 25 In Orringer MB, Heitmiller R (eds.) Shackelford's Surgery of the Alimentary Tract - 5th edition - Volume I - The Esophagus. W.B. Saunders Company, Philadelphia, 2002, pp. 407-442.
  10. Orringer MB. Complications of esophageal surgery. Chapter 26 In Orringer MB, Heitmiller R (eds.) Shackelford's Surgery of the Alimentary Tract - 5th edition - Volume I - The Esophagus. W.B. Saunders Company, Philadelphia, 2002, pp. 443-472.
  11. Orringer MB. Reflux stricture and short esophagus. Chapter 13 In Orringer MB, Heitmiller R (eds.) Shackelford's Surgery of the Alimentary Tract - 5th edition - Volume I - The Esophagus. W.B. Saunders Company, Philadelphia, 2002, pp. 224-245.
  12. Iannettoni MD, Orringer MB. Esophageal trauma. Chapter 27 In Orringer MB, Heitmiller R (eds.) Shackelford's Surgery of the Alimentary Tract - 5th edition - Volume I - The Esophagus. W.B. Saunders Company, Philadelphia, 2002, pp 475-493.
  13. Whyte RI, Deanda A, Jr., Orringer MB. Miscellaneous conditions of the esophagus. Chapter 29 In Orringer MB, Heitmiller R (eds.) Shackelford's Surgery of the Alimentary Tract - 5th edition - Volume I - The Esophagus. W.B. Saunders Company, Philadelphia, 2002, pp. 522-542.
  14. Vaitkevicius PV, Kirsh MM, Orringer MB. Perioperative evaluation and management. Chapter 30 In Hazzard WR, Blass JP, Halter JB, Ouslander JG, Tinetti ME (eds) Principles of Geriatric Medicine and Gerontology ? 5th edition. McGraw-Hill, New York, 2003, pp 361-371.
  15. Orringer MB. Transhiatal esophagectomy without thoracotomy. In Cohn LH, Patterson A (eds.) Operative Techniques in Thoracic and Cardiovascular Surgery, Spring 2005 Edition. Elsevier, Inc, Philadelphia, PA, pp. 63-83.
  16. Chang, AC, Orringer MB. Complications of esophageal surgery. In Yeo, CJ (ed.) Shackelford's Surgery of the Alimentary Tract - 6th edition - Volume I - The Esophagus. W.B. Saunders Company, Philadelphia, in press 6/2005
  17. Pickens, A, Orringer MB. Reflux induced stricture and the shortened esophagus. In Yeo CJ (ed.) Shackelford's Surgery of the Alimentary Tract - 6th edition - Volume I - The Esophagus. W.B. Saunders Company, Philadelphia, in press 6/2005.
  18. Orringer MB. Transhiatal esophagectomy. In Pearson FG, Cooper JD, Deslauriers J, Ginsberg RJ, Hiebert CA, Patterson GA, Urschel HC, Jr. (eds). Esophageal Surgery ? 3rd edition. Elsevier, Inc., Philadelphia, PA. Submitted 2/2006.
  19. Orringer MB, Transhiatal esophagectomy. In Kaiser L & Jamieson GG (eds). Operative Thoracic Surgery, 5th edition. Edward Arnold, Ltd., London, England. Submitted 2/2006.
  20. Orringer MB, Transhiatal esophagectomy without thoracotomy: In Fischer J (ed.) Mastery of Surgery ? 5th edition. Lippincott, Williams & Wilkins, Philadelphia. Submitted 4/2006.