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Randall S. Sung, MD
Randall S. Sung, M.D.
Randall S. Sung, M.D.
Associate Professor of Surgery

University of Michigan Health Systems
2926D Taubman Health Center
1500 East Medical Center Drive
Ann Arbor, MI 48109-5331
biography

I am a co-investigator on the Scientific Registry of Transplant Recipients (SRTR), which is funded by the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services. In my role for the SRTR, I support the Organ Procurement and Transplantation Network (OPTN) in transplant policy development, and contribute to the development of methodologies for modeling and maximizing organ utilization. My research is focused on deceased donor organ utilization and the outcomes of high-risk organ transplantation. The evaluation of potentially marginal kidney donors, including expanded criteria donor and donor after cardiac death by modalities such as biopsy and machine perfusion, is a particular interest. I have specifically studied the allocation and use of expanded criteria donor (ECD) kidneys. We have published a series of three articles describing the effectiveness of a revised deceased donor kidney allocation policy that was designed to increase the efficiency of ECD kidney allocation, increase utilization, and reduce ECD kidney discard.

Additional research effort is focused on transplant options for the treatment of diabetes. These efforts include bench research investigating determinants of human islet viability, the use of gene therapy to promote early islet survival following transplantation, the effects of islet shipping on islet viability, and human islet transplantation using islets shipped from remote facilities. Clinical research interests focus upon outcomes assessments in pancreas transplantation, including pancreas utilization, donor risk assessment metrics, and the survival benefit of pancreas transplantation.

I am also spearheading the development of a Biobank supported by the University of Michigan Transplant Center. This is a multidisciplinary effort designed to facilitate the development of translational research and biomarker discovery in transplantation. In this role, I have oversight over the collection and storage of serum, tissue and urine samples from living and deceased donors, from recipients in the surgical phase of the transplant process, and over the storage and disposition of samples from donors and transplant recipients. The biobank is expected to become operational in the summer of 2009.

Recent related publications:

  1. Cheng J, Sun J, Sung RS. Immunity to islet grafts transduced with adenovirus vectors does not inhibit long-term islet function. Transplant Immunology 2009; 21: 33-42.
  2. Tuttle-Newhall JE, Krishnan SM, Levy MF, McBride V, Orlowski JB, Sung RS. Organ donation and utilization in the United States, 1998-2007. American Journal of Transplantation 2009: 9 (4p2); 869-878.
  3. Sung RS, Christensen LL, Leichtman AB, Greenstein SM, Distant DA, Wynn JJ, Stegall MD, Delmonico FL, Port FK. Determinants of discard of expanded criteria donor kidneys: Impact of biopsy and machine perfusion. American Journal of Transplantation 2008: 8; 783-792.
  4. Sung RS, Guidinger MK, Leichtman AB, Lake C, Metzger RP, Port FK, Merion RM. Impact of the expanded criteria donor (ECD) allocation system on candidates for and recipients of ECD kidneys. Transplantation 2007; 84: 1138-1145.
  5. Cohn JA, Englesbe MJ, Ads Y, Paruch J, Pelletier SJ, Welling TH, Sonneday C, Magee JC, Punch JD, Campbell DA Jr, Sung RS. Financial implications of pancreas transplant complications and the role for quality improvement. American Journal of Transplantation 2007; 7: 1656-1660.