Mark B. Orringer, M.D.
Professor and Head, Section of Thoracic Surgery
John Alexander Distinguished Professor
Co-Director, Thoracic Oncology Program
Dr. Orringer is currently collaborating with David Beer, Ph.D., Director of the Thoracic Surgery Tumor Biology Program to define unique genetic markers in thoracic malignancies which may ultimately have both prognostic and therapeutic implications. This collaborative effort involves harvesting of fresh tumor tissue for DNA and RNA analysis in the thoracic surgery laboratory and concurrent correlation between clinical tumor stage, the presence of particular genetic markers, and prognosis.
Dr. Orringer is involved in a variety of clinical research projects involving assessment of the long-term efficacy of antireflux operations, particularly the combined Collis-Nissen repair, and optimal methods of resection and replacement of the esophagus, particularly using transhiatal esophagectomy and a cervical esophagogastric anastomosis for both benign and malignant disease. In addition, as Director of the Thoracic Oncology Program of the University of Michigan Cancer Center, Dr. Orringer coordinates several multidisciplinary clinical research protocols for the treatment of thoracic malignancies.
Key words: Thoracic, lung, esophagus, cancer