Jose Antonio Diaz, MD is a Research Investigator of the Section of Vascular Surgery, Department of Surgery at the University of Michigan. Dr. Diaz received his medical degree from the University of Buenos Aires Medical School in Argentina. He completed his General Surgery Residency and Vascular Surgery training in Argentina before moving to the United States. Dr. Diaz performed a 2 year fellowship in Vascular Biology at the University of Michigan in Dr. Keith Bishop's laboratory. Dr. Diaz subsequently became a research faculty of Vascular Surgery Section, in the Conrad Jobst Vascular Laboratory at University of Michigan.

Dr. Diaz's research interests are in the mechanism involved in deep vein thrombosis (DVT), specifically the link between inflammation and thrombogenesis, potential therapeutic targets for DVT and animal models in DVT. During his fellowship, Dr. Diaz and Dr. Bishop studied the role for interleukin 6 (IL-6) in hypertrophy and fibrosis in chronic cardiac allograft rejection. These studies revealed that IL-6 may serve as a potential therapeutic target to ameliorate both hypertrophy and fibrosis associated to chronic cardiac rejection. Recently, Dr. Diaz led the development of a new mouse model to study DVT that generate consistent vein thrombus within the inferior vena cava in the presence of constant blood flow: The Electrolytic IVC Model (EIM).

Currently Dr. Diaz is investigating the following: 1. P-selectin inhibition and DVT; 2. The effect of statins in DVT; 3. The role of PAI-1 in DVT; 4. EIM as a mouse model to acute and chronic DVT; 5. Development of a new swine model of DVT; 5 Stents and vein thrombosis.

Related Websites

• Conrad Jobst Vascular Research Laboratory